Investigating protein networks and mechanisms that regulate protein trafficking, signalling and organelle function
The Apaja Group is investigating the protein networks and molecular mechanisms that regulate membrane trafficking and proteostasis in human cells.
An important aspect is to gain a molecular-level understanding of how cellular stress responses change membrane organelle function, protein degradation, pH and calcium regulation and signalling events including ubiquitin signalling. The combined dynamics regulate proteostasis and is monitored by protein quality control machinery.
