​The Biro group are primarily concerned with the cell biology and mechanics of the actin cytoskeleton, and how immune cells (T cells) locate and kill cancer cells.

The group uses high-speed imaging to watch how T cells, and the cancer cells they target, move throughout complex 3-dimensional environments.

They also use single molecule microscopes to observe the dynamics of actin, which is a major component of the cytoskeleton.

The Biro and Rossy groups
From left to right: Feyza Colakoglu (research assistant), Maté Biro (group leader), Jorge Luis Galeano Niño (PhD student), Daryan Kempe (postdoc), Manuela Ecker (PhD student, Rossy lab), Matt Govendir (PhD student), Natasha Kaushik (research assistant, Rossy lab), Jacqueline Tearle (PhD student), Sophie Pageon (postdoc), Gregory Redpath (postdoc, Rossy lab), Haig Vartoukian (Honours student, Rossy lab), Jérémie Rossy (visiting group leader).
  • How T cell’s cytoskeleton drives the scanning for and interactions with tumour cells once located in the body
  • Migration of T cells through the body
  • See and quantitate the intricate dynamics and interactions of actin
Published In

Tay SS, Carol H, Biro M.

TriKEs and BiKEs join CARs on the cancer immunotherapy highway.

Hum Vaccin Immunother. 2016 Jun 20:1-7. [Epub ahead of print]

Galeano Niño JL, Kwan RY, Weninger W, Biro M.

Antigen-specific T cells fully conserve antitumour function following cryopreservation.

Immunol Cell Biol. 2016 Jan 12. doi: 10.1038/icb.2015.105. [Epub ahead of print]

Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford JB.

Emergence of an apical epithelial cell surface In vivo.

Dev Cell 2016 Jan 11;36(1):24-35. doi: http://dx.doi.org/10.1016/j.devcel.2015.12.013

Tong PL, Roediger B, Kolesnikoff N, Biro M, Tay SS, Jain R, Shaw LE, Grimbaldeston MA, Weninger W.

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

J Invest Dermatol. 2015 Jan;135(1):84-93. doi: 10.1038/jid.2014.289. Epub 2014 Aug 9.

Newman P, Lu Z, Roohani-Esfahani SI, Church TL, Biro M, Davies B, King A, Mackenzie K, Minett AI, Zreiqata H.

Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering.

J Mater Chem. B 2015;3:8337-8347. doi: 10.1039/C5TB01052G. Epub 2015 Sep 4

Biro M, Maître JL.

Dual pipette aspiration: a unique tool for studying intercellular adhesion.

Methods Cell Biol. 2015;125:255-67. doi: 10.1016/bs.mcb.2014.10.007. Epub 2015 Jan 8.

Biro M, Munoz MA, Weninger W.

Targeting Rho-GTPases in immune cell migration and inflammation.

Br J Pharmacol. 2014 Dec;171(24):5491-506. doi: 10.1111/bph.12658. Epub 2014 Jul 2.

Munoz MA, Biro M, Weninger W.

T cell migration in intact lymph nodes in vivo.

Curr Opin Cell Biol. 2014 Oct;30:17-24. doi: 10.1016/j.ceb.2014.05.002. Epub 2014 Jun 5.

Bovellan M, Romeo Y, Biro M, Fritzsche M, Boden A, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Paluch E, Roux PP, Charras G.

Cellular control of cortical actin nucleation.

Curr Biol. 2014 Jul 21;24(14):1628-35. doi: 10.1016/j.cub.2014.05.069. Epub 2014 Jul 10.

Weninger W, Biro M, Jain R.

Leukocyte migration in the interstitial space of non-lymphoid organs.

Nature Reviews Immunology. 2014;14(4): 232-246. doi:10.1038/nri3641. Epub 07 March 2014

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch E.

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cytoskeleton (Hoboken). 2013 Nov;70(11):741-54. doi: 10.1002/cm.21142. Epub 2013 Oct 17.

Sedzinski J*, Biro M*, Oswald A, Tinevez JY, Salbreux G, Paluch E. (* equal contribution)

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow.

Nature. 2011 Aug 7;476(7361):462-6. doi: 10.1038/nature10286.