Robert Weatheritt leads a research group that focusses on understanding the role of alternative splicing in expanding phenotypic complexity in primates, especially in the nervous system.

In line with this focus, the Weatheritt Group’s main aim is to uncover the root causes of neurodevelopmental disorders, such as autism spectrum disorder, and develop novel therapeutic interventions. 

Dr Robert Weatheritt completed his Ph.D. with Dr Toby Gibson at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany.

He was then awarded the prestigious Marie Curie postdoctoral fellowship to work with professors Ben Blencowe and Madan Babu at the Donnelly Centre for Cellular and Biomolecular Research in Toronto, Canada, and the MRC Laboratory of Molecular Biology in Cambridge, UK, respectively.

Dr Weatheritt has been an EMBL Australia group leader since 2018 and is based at the Garvan Institute in Sydney. Dr Weatheritt has published 25 highly cited peer-reviewed papers (seven papers with more than 100 citations), most of them in high-profile journals (including Science, Cell, Nat Struc Biol, Mol Cell, TIBS, E-Life, Chemical Reviews and Sci Signal).

His research group uses computational and system biology approaches to investigate how post-transcriptional processes regulate protein function in the nervous system.

Authors
Title
Published In

Gueroussov S, Weatheritt RJ, O’Hanlon D, Lin ZY, Gingras AC, Blencowe BJ.

Mammalian-specific regulation of higher-order hnRNP protein assemblies controls alternative splicing.

Cell (2017), 170(2): 324-339.

Weatheritt RJ, Sterne-Weiler T, Blencowe BJ.

The ribosome-engaged landscape of alternative splicing.

Nat Struct Mol Biol. (2016), 23(12): 1117-1123.

Irimia M, Weatheritt RJ, Ellis JD, Parikshak NN, Gonatopoulos-Pournatzis T,Babor M, Quesnel-Vallières M, Tapial J, Raj B, O'Hanlon D, Barrios-Rodiles M, Sternberg MJ, Cordes SP, Roth FP, Wrana JL, Geschwind DH, Blencowe BJ.

A highly conserved program of neuronal microexons is misregulatedin autistic brains.

Cell (2014), 159(7):1511-23.

Weatheritt RJ, Babu MM.

Evolution: The hidden codes that shape protein evolution.

Science (2013), 342(6164).