The Mäkinen Group are focused on determining the molecular patterns of gene and protein expression that cause chronic and age-related conditions such as obesity, diabetes and cardiovascular disease.
As part of their research, the group develops and uses computational approaches to analyse the huge datasets generated by genomics, transcriptomics and metabolomics studies, looking for patterns linking genes and proteins to the physical characteristics of disease.
Research
By integrating epidemiological and clinical data from large population studies with genomic and gene/protein expression data, the group can create hypotheses of possible disease mechanisms which can then be tested and validated both in vitro and in live animal studies.
The Group combine the systematic analyses of multiple diseases and metabolic traits to get a detailed understanding of the molecular life paths of individuals and the context-dependent risk factors that predispose to morbidity in later life.
