Cell Motility and Mechanobiology

The Biro Group investigates how immune cells locate and kill cancer cells, adopting multi-disciplinary methods encompassing biophysics, cell biology, immunology, cancer biology, advanced microscopy, image analysis, and mathematical and coputational modelling. 

Biro Group 2019

From left to right: Jorge Luis Galeano Niño (PhD student), Daryan Kempe (postdoc), Manuela Ecker (PhD student, Rossy lab), Sophie Pageon (postdoc), Feyza Colakoglu (research assistant), Maté Biro (group leader), Szun Szun Tay (postdoc), Jessica Mazalo (PhD student), James Cremasco (PhD student), Satya Arjunan (postdoc), Jacqueline Tearle (PhD student), Florence Piastra-Facon (visiting student, ENS Lyon), Matt Govendir (PhD student).

Name
Position
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  • Killer immune cell motility and search for cancer cells
  • Emergent/collective behaviour in immune cell populations
  • Mechanics of cytotoxic interactions between immune cells and tumour cells
  • Search strategy optimisation (theory and computational modelling)
  • Imaging and quantification of actin cytoskeleton dynamics
  • Mechanics of motility and cell polarisation

Highlight publications

Authors
Title
Published In

Obeidy, P., Lining, J., Oehlers, S., Zulkhernain, N., Lee, Q., Galeano Niño, J., Kwan, R., Tikoo, S., Cavanagh, L., Mrass, P., Cook, A., Jackson, S., Biro, M., Roediger, B., Sixt, M., Weninger, W. (2019)

Partial loss of actin nucleator Actin Related Protein 2/3 activity triggers blebbing in primary T lymphocytes

Redpath G.M.I., Ecker M., Kapoor-Kaushik N., Vartoukian H., Carnell M., Kempe D., Biro M., Ariotti N., Rossy J. (2019)

Flotillins promote T cell receptor sorting through a fast Rab5-Rab11 endocytic recycling axis

Meiring J., Bryce N., Galeano Niño J.L., Gabriel A., Tay S.S., Hardeman E., Biro M., Gunning P. (2019)

Tropomyosin concentration but not formin nucleators mDia1 and mDia3 determines the level of tropomyosin incorporation into actin filaments

Mitchell C.B., Black B., Sun F., Chrzanowski W., Cooper-White J., Maisonneuve B., Stringer B., Day B., Biro M., O’Neill G.M. (2018)

Tropomyosin Tpm 2.1 loss induces glioblastoma spreading in soft brain-like environments

Moran I., Nguyen A., Khoo W.H., Butt D., Bourne K., Young C., Hermes J.R., Biro M., Gracie G., Ma C.S., Munier C.M.L., Luciani F., Zaunders J., Parker A., Kelleher A.D., Tangye S.G., Croucher P.I., Brink R., Read M.N., Phan T.G. (2018)

Memory B cells are reactivated in subcapsular proliferative foci of lymph nodes

Pageon S.V., Govendir M.A., Kempe D., Biro M. (2018)

Mechanoimmunology: molecular-scale forces govern immune cell functions

Zenker J., White M.D., Gasnier M., Alvarez Y.D., Lim H.Y.G., Bissiere S., Biro M.*, Plachta N.* (2018)

(*senior and corresponding author) 

Expanding Actin Rings Zipper the Mouse Embryo for Blastocyst Formation

Cell 173(3):776-791.e17

Chou J., Poole K., Biro M. (2017)

Your body’s cells use and resist force, and they move. It’s mechanobiology.

The Conversation October 20, 2017

Sedzinski J., Hannezo E., Tu F., Biro M., and Wallingford J. (2017)

RhoA regulates actin network dynamics during apical surface emergence in multiciliated epithelial cells

Journal of Cell Science 130(2): 420-428

Marshall A.D., Bailey C.G., Champ K., Vellozzi M., O’Young P., Metierre C., Feng Y., Thoeng A., Richards A.M., Schmitz U., Biro M., Jayasinghe R., Ding L., Anderson L., Mardis E.R., Rasko J.E.J. (2017)

CTCF Genetic Alterations in Endometrial Carcinoma are Pro-tumorigenic 

Oncogene 36(29):4100-4110

Newman P., Galenano Niño J.L., Graney P., Razal J.M., Minett A.I., Ribas J., Ovalle-Robles R., Biro M.*, Zreiqat H.* (2016)

(*senior and corresponding author)

Relationship between nanotopographical alignment and stem cell fate with live imaging and shape analysis 

Scientific Reports 6:37909 doi: 10.1038/srep37909

Tay SS, Carol H, Biro M. (2016)

TriKEs and BiKEs join CARs on the cancer immunotherapy highway.

Galeano Niño JL, Kwan RY, Weninger W, Biro M. (2016)

Antigen-specific T cells fully conserve antitumour function following cryopreservation.

Immunology and Cell Biology 94(4): 411-418 

Sedzinski J, Hannezo E, Tu F, Biro M, Wallingford JB. (2016)

Emergence of an apical epithelial cell surface In vivo.

Developmental Cell 36(1):24-35

Newman P, Lu Z, Roohani-Esfahani SI, Church TL, Biro M, Davies B, King A, Mackenzie K, Minett AI, Zreiqat H. (2015)

Porous and strong three-dimensional carbon nanotube coated ceramic scaffolds for tissue engineering.

Tong PL, Roediger B, Kolesnikoff N, Biro M, Tay SS, Jain R, Shaw LE, Grimbaldeston MA, Weninger W. (2015)

The skin immune atlas: three-dimensional analysis of cutaneous leukocyte subsets by in vivo microscopy

Biro M, Maître JL. (2015)

Dual pipette aspiration: a unique tool for studying intercellular adhesion.

Munoz MA*, Biro M*, Weninger W. (2014)

(*equal contribution)

T cell migration in intact lymph nodes in vivo.

Biro M*, Munoz MA, Weninger W. (2014)

(*corresponding author)

Targeting Rho-GTPases in immune cell migration and inflammation.

Weninger W, Biro M, Jain R. (2014)

Leukocyte migration in the interstitial space of non-lymphoid organs.

Bovellan M, Romeo Y, Biro M, Fritzsche M, Boden A, Moulding D, Thorogate R, Jégou A, Thrasher AJ, Romet-Lemonne G, Paluch E, Roux PP, Charras G. (2014)

Cellular control of cortical actin nucleation

Current Biology 24(14):1628-1635

Biro M, Romeo Y, Kroschwald S, Bovellan M, Boden A, Tcherkezian J, Roux PP, Charras G, Paluch E. (2013)

Cell cortex composition and homeostasis resolved by integrating proteomics and quantitative imaging.

Cytoskeleton 70(11):741-754

Sedzinski J*, Biro M*, Oswald A, Tinevez JY, Salbreux G, Paluch E. (2011)

(*equal contribution)

Polar actomyosin contractility destabilizes the position of the cytokinetic furrow.

Nature 476(7361):462-466

Puah W.C., Cheok L.P., Biro M., Ng W.T., Wasser M. (2011)

TLM-Converter: reorganization of long time-lapse microscopy datasets for downstream image analysis

BioTechniques 51(1): 49-54