The Zhang Group is interested in understanding the fundamental mechanisms of epigenetic regulation.
Dr Qi Zhang’s lab primarily investigates the role of chromatin-modifying complexes in gene regulation and cancer, with the ultimate goal of translating fundamental lab-based discoveries into novel therapeutic strategies.
To achieve this, her lab employs a diverse range of methodologies, including biochemistry, structural biology, cell biology, genomics and bioinformatics.
Read more on the Zhang Lab webpage.
- Epigenetic and gene regulation
- Chromatin and RNA biology
- Cancer biology
Highlight publications
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Nature Communications (2021) 12, 4592. |
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. |
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RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nature Structural & Molecular Biology (2019) 26(3):237-247. |
RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. |
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Proceedings of the National Academy of Sciences of the United States of America (2019) 116(15):7288-7297. |
Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. |