Contact Details
- Epigenetic and gene regulation
- Chromatin and RNA biology
- Cancer biology
Qi Zhang obtained her PhD in Biochemistry and Molecular Biology from China Agricultural University. She then pursued postdoctoral research at the Structural Genomics Consortium, University of Toronto, focusing on the structure and function of ubiquitination complexes in stress response and gene regulation.
Subsequently, Qi joined the Chen Davidovich lab at the Monash Biomedicine Discovery Institute (BDI), where she studied how PRC2 is regulated by protein and RNA cofactors, supported by ARC DECRA and an NHMRC Investigator grant.
In December 2023, she established her own lab as an EMBL Australia Group Leader at the South Australian immunoGENomics Cancer Institute (SAiGENCI), at the University of Adelaide. Read more about the group on the Zhang Lab webpage.
Highlight publications
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Nature Communications (2021) 12, 4592. |
PALI1 facilitates DNA and nucleosome binding by PRC2 and triggers an allosteric activation of catalysis. |
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RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. Nature Structural & Molecular Biology (2019) 26(3):237-247. |
RNA exploits an exposed regulatory site to inhibit the enzymatic activity of PRC2. |
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Proceedings of the National Academy of Sciences of the United States of America (2019) 116(15):7288-7297. |
Crystal structure and activity-based labeling reveal the mechanisms for linkage-specific substrate recognition by deubiquitinase USP9X. |